First Isolation of Neoscytalidium dimidiatum from Human Dermatomycosis in Japan.
Med Mycol J
; 63(3): 71-75, 2022.
Article
em En
| MEDLINE
| ID: mdl-36047185
ABSTRACT
Neoscytalidium dimidiatum is a common fungus that causes non-dermatophyte dermatomycosis in tropical regions, but there have been no reports of infection with N. dimidiatum in Japan. Here, we report the first isolation of N. dimidiatum from human dermatomycosis in Japan. A 62-year-old healthy Japanese male had been treated with oral terbinafine for tinea pedis diagnosed from a microscopic examination in 2003 with a lesion that was intractable. In 2020, re-identification by sequencing the internal transcribed spacer regions and the D1/D2 domain of the large-subunit (LSU) ribosomal RNA gene revealed that the pathogen was N. dimidiatum. Antifungal susceptibility tests showed that the minimum inhibitory concentration of the drug luliconazole (LLCZ) against the pathogen was 0.00049 µg/mL. The patient's lesions were cured by topical LLCZ. The clinical course and drug susceptibility suggest that LLCZ is a suitable first-line drug for treatment.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Antifúngicos
Limite:
Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Med Mycol J
Ano de publicação:
2022
Tipo de documento:
Article