Depletion of Foxp3+ regulatory T cells but not the absence of CD19+IL-10+ regulatory B cells hinders tumor growth in a para-orthotopic neuroblastoma mouse model.

Weißenborn, Christine; von Lenthe, Sophie; Hinz, Nicole; Langwisch, Stefanie; Busse, Mandy; Schumacher, Anne; Zenclussen, Ana C; Fest, Stefan

Weißenborn, Christine; von Lenthe, Sophie; Hinz, Nicole; Langwisch, Stefanie; Busse, Mandy; Schumacher, Anne; Zenclussen, Ana C; Fest, Stefan.

Afiliação

Weißenborn C; Pediatric Immunotherapy Group, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
von Lenthe S; Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
Hinz N; Pediatric Immunotherapy Group, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
Langwisch S; Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
Busse M; Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
Schumacher A; Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
Zenclussen AC; Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.
Fest S; Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Int J Cancer ; 151(11): 2031-2042, 2022 Dec 01.

Article em En | MEDLINE | ID: mdl-36054664

Assuntos

Linfócitos B Reguladores; Neuroblastoma; Animais; Antígenos CD19; Linfócitos B Reguladores/metabolismo; Toxina Diftérica/metabolismo; Toxina Diftérica/farmacologia; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/metabolismo; Interleucina-10/metabolismo; Interleucina-4/metabolismo; Interleucina-6/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Neuroblastoma/metabolismo; Linfócitos T Reguladores; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Bregs; Tregs; immune escape mechanism; neuroblastoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B Reguladores / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Cancer Ano de publicação: 2022 Tipo de documento: Article

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