Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca<sup>2+</sup> Overload.

Wu, Ne N; Bi, Yaguang; Ajoolabady, Amir; You, Fei; Sowers, James; Wang, Qiurong; Ceylan, Asli F; Zhang, Yingmei; Ren, Jun

Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca²⁺ Overload.

Wu, Ne N; Bi, Yaguang; Ajoolabady, Amir; You, Fei; Sowers, James; Wang, Qiurong; Ceylan, Asli F; Zhang, Yingmei; Ren, Jun.

Afiliação

Wu NN; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Bi Y; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Ajoolabady A; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
You F; Department of Cardiology, Xi'an Central Hospital, Xi'an, China.
Sowers J; Diabetes and Cardiovascular Research Center, University of Missouri Columbia, Columbia, Missouri, USA.
Wang Q; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Ceylan AF; Faculty of Medicine, Department of Medical Pharmacology, Ankara Yildirim Beyazit University, Bilkent, Ankara, Turkey.
Zhang Y; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Ren J; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

JACC Basic Transl Sci ; 7(8): 779-796, 2022 Aug.

Article em En | MEDLINE | ID: mdl-36061337

Palavras-chave

AMCM, adult murine cardiomyocyte; BP, blood pressure; Ca2+ overload; HFD, high-fat diet; LFD, low-fat diet; LV, left ventricular; MCU, mitochondrial Ca2+ uniporter; PA, palmitic acid; Parkin; ROS, reactive oxygen species; TR90, time to 90% relengthening; VDAC, voltage-dependent anion channel; VDAC1; WT, wild-type; heart; high-fat diet; mPTP, mitochondrial permeability transition pore; mitochondria

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2022 Tipo de documento: Article