Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72-ALS.

Rifai, Olivia M; Longden, James; O'Shaughnessy, Judi; Sewell, Michael DE; Pate, Judith; McDade, Karina; Daniels, Michael Jd; Abrahams, Sharon; Chandran, Siddharthan; McColl, Barry W; Sibley, Christopher R; Gregory, Jenna M

Rifai, Olivia M; Longden, James; O'Shaughnessy, Judi; Sewell, Michael DE; Pate, Judith; McDade, Karina; Daniels, Michael Jd; Abrahams, Sharon; Chandran, Siddharthan; McColl, Barry W; Sibley, Christopher R; Gregory, Jenna M.

Afiliação

Rifai OM; Translational Neuroscience PhD Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Longden J; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
O'Shaughnessy J; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Sewell M; Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
Pate J; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McDade K; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Daniels MJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Abrahams S; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Chandran S; Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
McColl BW; Translational Neuroscience PhD Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sibley CR; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Gregory JM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

J Pathol ; 258(4): 366-381, 2022 12.

Article em En | MEDLINE | ID: mdl-36070099

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Humanos; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/patologia; Proteína C9orf72/genética; Demência Frontotemporal/genética; Demência Frontotemporal/patologia; Microglia/patologia; Mutação

Palavras-chave

C9orf72; TDP-43; amyotrophic lateral sclerosis; digital pathology; frontotemporal dementia; fused in sarcoma (FUS); machine learning; microglia; neuroinflammation; post-mortem tissue

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Esclerose Lateral Amiotrófica Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: J Pathol Ano de publicação: 2022 Tipo de documento: Article

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