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T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease.
Jacobsen, Marc; Adjei, Jonathan Kofi; Aniagyei, Wilfred; Adankwah, Ernest; Seyfarth, Julia; Mayatepek, Ertan; Antwi-Berko, Daniel; Sakyi, Samuel Asamoah; Debrah, Alexander Y; Debrah, Linda Batsa; Owusu, Dorcas O; Phillips, Richard O.
Afiliação
  • Jacobsen M; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
  • Adjei JK; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
  • Aniagyei W; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
  • Adankwah E; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
  • Seyfarth J; Department of Medical Diagnostics, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
  • Mayatepek E; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
  • Antwi-Berko D; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
  • Sakyi SA; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
  • Debrah AY; Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
  • Debrah LB; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
  • Owusu DO; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
  • Phillips RO; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
J Pediatric Infect Dis Soc ; 11(12): 575-577, 2022 Dec 28.
Article em En | MEDLINE | ID: mdl-36070406
ABSTRACT
Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n = 20) but only ratios (PPDMtub/PPDMulc) discriminated the study groups efficiently.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Mycobacterium ulcerans / Úlcera de Buruli / Mycobacterium tuberculosis Limite: Child / Humans Idioma: En Revista: J Pediatric Infect Dis Soc Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Mycobacterium ulcerans / Úlcera de Buruli / Mycobacterium tuberculosis Limite: Child / Humans Idioma: En Revista: J Pediatric Infect Dis Soc Ano de publicação: 2022 Tipo de documento: Article