Determination of Predictors of Brain Injury in Very Preterm Infants - A Retrospective Cohort Study.
Neurol India
; 70(4): 1610-1614, 2022.
Article
em En
| MEDLINE
| ID: mdl-36076666
ABSTRACT
Background:
Despite decades of research, there is inadequate evidence on the etiological factors of brain injury in preterm infants.Objective:
To study the perinatal risk factors for preterm brain injury and to assess their strength of association.Methods:
In this retrospective cohort study, we included infants born at <32 weeks' gestation and had either magnetic resonance imaging (MRI) or cranial ultrasound (CUS) performed at term equivalent age. Significant brain injury was diagnosed based on Kidokoro global brain injury score was ≥4 in MRI or cystic periventricular leukomalacia in CUS.Results:
Among the 698 infants, 48 had significant brain injury and 650 were taken as controls. In multiple logistic regression, intraventricular hemorrhage (IVH) grade 3-4 [adjusted odds ratio, 92.892 (19.495-442.619)], culture-positive sepsis [4.162 (1.729-10.021)], prolonged ventilation [3.688 (1.087-12.510)], and small for gestational age (SGA) [2.645 (1.181-5.924] were associated with greater risk of preterm brain injury.Conclusion:
Severe IVH, culture-positive sepsis, prolonged ventilation and SGA were significant risk factors for preterm brain injury with severe IVH being the most significant contributing factor.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Sepse
/
Doenças do Prematuro
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Revista:
Neurol India
Ano de publicação:
2022
Tipo de documento:
Article