Cationic, amphipathic small molecules based on a triazine-piperazine-triazine scaffold as a new class of antimicrobial agents.

Dinesh Kumar, S; Park, Jun Hyung; Kim, Hyun Soo; Seo, Chang Deok; Ajish, Chelladurai; Kim, Eun Young; Lim, Hyun-Suk; Shin, Song Yub

Dinesh Kumar, S; Park, Jun Hyung; Kim, Hyun Soo; Seo, Chang Deok; Ajish, Chelladurai; Kim, Eun Young; Lim, Hyun-Suk; Shin, Song Yub.

Afiliação

Dinesh Kumar S; Department of Cellular & Molecular Medicine, School of Medicine, Chosun University, Gwangju, 61452, Republic of Korea.
Park JH; Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Kim HS; Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Seo CD; Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Ajish C; Department of Cellular & Molecular Medicine, School of Medicine, Chosun University, Gwangju, 61452, Republic of Korea.
Kim EY; Department of Cellular & Molecular Medicine, School of Medicine, Chosun University, Gwangju, 61452, Republic of Korea.
Lim HS; Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea. Electronic address: hslim@postech.ac.kr.
Shin SY; Department of Cellular & Molecular Medicine, School of Medicine, Chosun University, Gwangju, 61452, Republic of Korea. Electronic address: syshin@chosun.ac.kr.

Eur J Med Chem ; 243: 114747, 2022 Dec 05.

Article em En | MEDLINE | ID: mdl-36103802

Assuntos

Anti-Infecciosos; Peptídeos Catiônicos Antimicrobianos; Peptídeos Catiônicos Antimicrobianos/química; Testes de Sensibilidade Microbiana; Lipopolissacarídeos/farmacologia; Lipopolissacarídeos/química; Triazinas/farmacologia; Piperazina/farmacologia; Anti-Infecciosos/farmacologia; Biofilmes; Antibacterianos/farmacologia; Antibacterianos/química

Palavras-chave

Anti-inflammatory activity; Antibiofilm activity; Antimicrobial activity; Antimicrobial peptide; Small molecule proteolytic stability; Triazine-piperazine-triazine scaffold

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Catiônicos Antimicrobianos / Anti-Infecciosos Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article

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