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Natural polysaccharides as potential anti-fibrotic agents: A review of their progress.
Wang, Ming; Lu, Simin; Zhao, Hui; Liu, Ziyi; Sheng, Kangjia; Fang, Jiacheng.
Afiliação
  • Wang M; College of Food Science & Engineering, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address: wangming@nwu.edu.cn.
  • Lu S; College of Food Science & Engineering, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
  • Zhao H; Clinical Experimental Center, Xi'an International Medical Center Hospital, Xi'an, Shaanxi 710100, China.
  • Liu Z; College of Food Science & Engineering, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
  • Sheng K; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
  • Fang J; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, RRS812 Kowloon Tong, Hong Kong.
Life Sci ; 308: 120953, 2022 Nov 01.
Article em En | MEDLINE | ID: mdl-36103957
Fibrosis, as a common disease which could be found in nearly all organs, is normally initiated by organic injury and eventually ended in cellular dysfunction and organ failure. Currently, effective and safe therapeutic strategies targeting fibrogenesis still in highly demand. Natural polysaccharides derived from natural resources possess promising anti-fibrosis potential, with no deleterious side effects. Based on the etiology and pathogenesis of fibrosis, this review summarizes the intervention effects and mechanisms of natural polysaccharides in the prevention and treatment of fibrosis. Natural polysaccharides are able to regulate each phase of the fibrogenic response, including primary injury to organs, activation of effector cells, the elaboration of extracellular matrix (ECM) and dynamic deposition. In addition, polysaccharides significantly reduce fibrosis levels in multiple organs including heart, lung, liver and kidney. The investigation of the pathogenesis of fibrosis indicates that mechanisms including the inhibition of TGF-ß/Smad, NF-κB, HMGB1/TLR4, cAMP/PKA signaling pathways, MMPs/TIMPs system as well as microRNAs are promising therapeutic targets. Natural polysaccharides can target these mediators or pathways to alleviate fibrosis. The information reviewed here offer new insights into the understanding the protective role of natural polysaccharides against fibrosis, help design further experimental studies related to polysaccharides and fibrotic responses, and shed light on a potential treatment for fibrosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína HMGB1 / MicroRNAs Limite: Humans Idioma: En Revista: Life Sci Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína HMGB1 / MicroRNAs Limite: Humans Idioma: En Revista: Life Sci Ano de publicação: 2022 Tipo de documento: Article