Iridium-Catalyzed Enantioselective Direct α-C-H Alkylation of Saturated Cyclic Amines with Alkenes.
Org Lett
; 24(37): 6828-6833, 2022 Sep 23.
Article
em En
| MEDLINE
| ID: mdl-36106719
ABSTRACT
Enantioselective direct α-C(sp3)-H alkylation of saturated cyclic amines having N-methylbenzimidazolyl as a directing group was realized by using a cationic iridium/chiral diphosphine catalyst. The alkylation of pyrrolidine derivatives with various terminal alkenes proceeded to give α-alkylated products in high yields with high enantioselectivities. Chiral α,α'-dialkylated pyrrolidine derivatives were also synthesized by using an excess of alkenes or by stepwise alkylation.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2022
Tipo de documento:
Article