Effect of Pap smears on the long-term survival of cervical cancer patients: a nationwide population-based cohort study in Korea.
Epidemiol Health
; 44: e2022072, 2022.
Article
em En
| MEDLINE
| ID: mdl-36108672
ABSTRACT
OBJECTIVES:
This study aimed to investigate the effect of cervical cancer screening by Papanicolaou (Pap) smears on the long-term survival of cervical cancer patients.METHODS:
We constructed a retrospective cohort of 14,903 women diagnosed with invasive cancer or carcinoma in situ in 2008 and 2009 and followed up until December 31, 2019, by using individual-level data from 3 national databases of the Korean National Cancer Screening Program, the Korean Central Cancer Registry, and death certificates. Cox proportional-hazards regression was used to investigate the effect of cervical cancer screening on mortality.RESULTS:
In total, 12,987 out of 14,867 patients (87.4%) were alive at the end of the follow-up period (median 10.5 years). Screened patients had a 38% lower risk of cervical cancer death than never-screened patients (hazard ratio [HR], 0.62; 95% confidence interval [CI], 0.54 to 0.70). Screening was associated with 59% and 35% lower risks of death, respectively, in screened patients with localized and regional stages. Furthermore, lower HRs among women who received screening were observed in all age groups, especially women aged 50-59 years (HR, 0.54; 95% CI, 0.42 to 0.69). The lowest HR for cervical cancer death was reported among patients screened within the past 2 years (HR, 0.54; 95% CI, 0.47 to 0.63), and the HRs increased with increasing time intervals.CONCLUSIONS:
Pap smear screening significantly reduced the risk of cervical cancer-specific death in Korean women across all cancer stages.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
Teste de Papanicolaou
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
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Screening_studies
Limite:
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Epidemiol Health
Ano de publicação:
2022
Tipo de documento:
Article