An anticomplement homogeneous polysaccharide from Hedyotis diffusa attenuates lipopolysaccharide-induced acute lung injury and inhibits neutrophil extracellular trap formation.

Zhang, Jie; Huo, Jiangyan; Zhao, Zhizhi; Lu, Yan; Hong, Zhou; Li, Hong; Chen, Daofeng

Zhang, Jie; Huo, Jiangyan; Zhao, Zhizhi; Lu, Yan; Hong, Zhou; Li, Hong; Chen, Daofeng.

Afiliação

Zhang J; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai 201203, China.
Huo J; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai 201203, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Nanjing 210009, China.
Zhao Z; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai 201203, China.
Lu Y; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai 201203, China.
Hong Z; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai 201203, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Nanjing 210009, China.
Li H; Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. Electronic address: lxzhang@shmu.edu.cn.
Chen D; Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong New Area, Shanghai 201203, China. Electronic address: dfchen@shmu.edu.cn.

Phytomedicine ; 107: 154453, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36116199

Assuntos

Lesão Pulmonar Aguda; Armadilhas Extracelulares; Hedyotis; Lesão Pulmonar Aguda/induzido quimicamente; Lesão Pulmonar Aguda/tratamento farmacológico; Lesão Pulmonar Aguda/metabolismo; Animais; Quimiocinas/metabolismo; Complemento C3a/metabolismo; Complemento C3c/metabolismo; Proteínas Inativadoras do Complemento; Citocinas/metabolismo; Armadilhas Extracelulares/metabolismo; Histonas; Interleucina-6/metabolismo; Ligantes; Lipopolissacarídeos; Camundongos; Peroxidase/metabolismo; Polissacarídeos/farmacologia; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Acute lung injury; Anticomplement; Hedyotis diffusa; Lipopolysaccharide; Neutrophil extracellular trap; Polysaccharide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hedyotis / Lesão Pulmonar Aguda / Armadilhas Extracelulares Limite: Animals Idioma: En Revista: Phytomedicine Ano de publicação: 2022 Tipo de documento: Article

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