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Modern Solutions for Ancient Pathogens: Direct Pathogen Sequencing for Diagnosis of Lepromatous Leprosy and Cerebral Coenurosis.
Young, Bernadette C; Bush, Stephen J; Lipworth, Sam; George, Sophie; Dingle, Kate E; Sanderson, Nick; Brankin, Alice; Walker, Timothy; Sharma, Srilakshmi; Leong, James; Plaha, Puneet; Hofer, Monika; Chiodini, Peter; Gottstein, B; Furrer, Lavinia; Crook, Derrick; Brent, Andrew.
Afiliação
  • Young BC; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Bush SJ; Microbiology and Infectious Diseases Department, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Lipworth S; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • George S; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Dingle KE; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Sanderson N; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Brankin A; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Walker T; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Sharma S; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
  • Leong J; Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Plaha P; Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Hofer M; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
  • Chiodini P; Department of Neuropathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Gottstein B; Hospital of Tropical Diseases and the London School of Hygiene and Tropical Medicine London, London, United Kingdom.
  • Furrer L; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
  • Crook D; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
  • Brent A; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Open Forum Infect Dis ; 9(9): ofac428, 2022 Sep.
Article em En | MEDLINE | ID: mdl-36119959
ABSTRACT
Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2022 Tipo de documento: Article