Stratification Based on Risk Factors at Diagnosis Could Predict Progression in Patients with Pancreatic Cysts.
Dig Dis Sci
; 68(4): 1511-1518, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36125596
ABSTRACT
BACKGROUND:
Predicting the risk of malignant transformation in pancreatic cyst patients is challenging.AIM:
We retrospectively investigated the risk factors for malignant transformation in pancreatic cyst patients.METHODS:
Patients with pancreatic cysts diagnosed using imaging tests were followed from November 2008 to December 2021. A significant change was defined as the additional development of high-risk stigmata (HRS), worrisome features (WFs), or pancreatic cancer during monitoring.RESULTS:
In total, 479 patients were analyzed, with a median observation period of 50 months. Forty-four patients (9.2%) showed significant changes, and eight (1.7%) developed pancreatic cancer. The univariate analysis showed that the cyst diameter at diagnosis (≥ 14 mm), main pancreatic duct (MPD) diameter at diagnosis (≥ 3 mm), presence of multilocular cysts, and an inconsistent MPD caliber were significant predictive factors for a significant change. One point was assigned for each significant factor. We grouped the patients into three groups the low-risk group (total score 0), medium-risk group (score 1-2), and high-risk group (score 3-4). The high-risk group had a higher risk of a significant change than the medium- and low-risk groups (age-adjusted HRs for the medium-risk and high-risk groups were 3.0 and 5.2 compared with the low-risk group).CONCLUSION:
Stratification based on risk factors may help predict the development of significant changes in pancreatic cyst patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cisto Pancreático
/
Neoplasias Pancreáticas
/
Carcinoma Ductal Pancreático
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
2023
Tipo de documento:
Article