FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy.

Wang, Jia; Sha, Jian; Strong, Emily; Chopra, Ashok K; Lee, Sunhee

Wang, Jia; Sha, Jian; Strong, Emily; Chopra, Ashok K; Lee, Sunhee.

Afiliação

Wang J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Sha J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Strong E; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Chopra AK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Lee S; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

Microbiol Spectr ; 10(5): e0250922, 2022 10 26.

Article em En | MEDLINE | ID: mdl-36129262

Assuntos

Amoxapina; Mycobacterium tuberculosis; Tuberculose; Camundongos; Humanos; Animais; Amoxapina/metabolismo; Amoxapina/farmacologia; Vacina BCG; Mycobacterium tuberculosis/metabolismo; Macrófagos; Autofagia; Serina-Treonina Quinases TOR/metabolismo; Tuberculose/tratamento farmacológico; Tuberculose/metabolismo; Mamíferos/metabolismo

Palavras-chave

Mycobacterium tuberculosis; antidepressant; autophagy; host-directed therapeutics; mTOR; macrophages

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Tuberculose / Amoxapina / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Microbiol Spectr Ano de publicação: 2022 Tipo de documento: Article

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