Evaluation of a Raman Chemometric Method for Detecting Protein Structural Conformational Changes in Solution.

Fontana, Lauren; Anderson, Carl; Bogner, Robin; Pikal, Michael

Fontana, Lauren; Anderson, Carl; Bogner, Robin; Pikal, Michael.

Afiliação

Fontana L; Department of Pharmaceutical Science, University of Connecticut School of Pharmacy, 69 North Eagleville Road, Storrs, CT 06269-3092, USA; Sanofi, 15 Pleasant Street, Framingham, MA 01701, USA.
Anderson C; Duquesne University School of Pharmacy, 581 Forbes Avenue, Pittsburgh, PA 15219, USA.
Bogner R; Department of Pharmaceutical Science, University of Connecticut School of Pharmacy, 69 North Eagleville Road, Storrs, CT 06269-3092, USA. Electronic address: robin.bogner@uconn.edu.
Pikal M; Department of Pharmaceutical Science, University of Connecticut School of Pharmacy, 69 North Eagleville Road, Storrs, CT 06269-3092, USA.

J Pharm Sci ; 112(2): 573-586, 2023 02.

Article em En | MEDLINE | ID: mdl-36152698

Assuntos

Quimiometria; Proteínas; Conformação Proteica; Excipientes/química; Estrutura Terciária de Proteína; Análise Espectral Raman/métodos

Palavras-chave

Circular dichroism; Principal component analysis; Protein aggregation; Raman spectroscopy; Structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Quimiometria Tipo de estudo: Prognostic_studies Idioma: En Revista: J Pharm Sci Ano de publicação: 2023 Tipo de documento: Article

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