Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.

Cupo, Ryan R; Rizo, Alexandrea N; Braun, Gabriel A; Tse, Eric; Chuang, Edward; Gupta, Kushol; Southworth, Daniel R; Shorter, James

Cupo, Ryan R; Rizo, Alexandrea N; Braun, Gabriel A; Tse, Eric; Chuang, Edward; Gupta, Kushol; Southworth, Daniel R; Shorter, James.

Afiliação

Cupo RR; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA; Pharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rizo AN; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.
Braun GA; Chemistry and Chemical Biology Graduate Program, Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Tse E; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Chuang E; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA; Pharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gupta K; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Southworth DR; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: daniel.southworth@ucsf.edu.
Shorter J; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA; Pharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jshorter@pennmedicine.upenn.edu.

Cell Rep ; 40(13): 111408, 2022 09 27.

Article em En | MEDLINE | ID: mdl-36170828

Assuntos

Anquirinas; Proteínas de Choque Térmico; Trifosfato de Adenosina/metabolismo; Anquirinas/metabolismo; Proteínas de Choque Térmico/metabolismo; Humanos; Modelos Moleculares; Nucleotídeos/metabolismo; Transporte Proteico

Palavras-chave

AAA+ proteins, protein aggregation; CP: Cell biology; chaperone; disaggregase; mitochondria; mitochondrial disorders; therapeutics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anquirinas / Proteínas de Choque Térmico Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article

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