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Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.
Misehe, Mbilo; Klima, Martin; Matousová, Marika; Chalupská, Dominika; Dejmek, Milan; Sála, Michal; Mertlíková-Kaiserová, Helena; Boura, Evzen; Nencka, Radim.
Afiliação
  • Misehe M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, 128 43 Prague 2, Czech Republic.
  • Klima M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Matousová M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Chalupská D; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Dejmek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Sála M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Mertlíková-Kaiserová H; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Boura E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.
  • Nencka R; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic. Electronic address: nencka@uochb.cas.cz.
Bioorg Med Chem Lett ; 76: 129010, 2022 11 15.
Article em En | MEDLINE | ID: mdl-36184029
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / 1-Fosfatidilinositol 4-Quinase Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / 1-Fosfatidilinositol 4-Quinase Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2022 Tipo de documento: Article