A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Science
; 378(6615): 68-78, 2022 10 07.
Article
em En
| MEDLINE
| ID: mdl-36201590
ABSTRACT
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase (IDH)-mutant low-grade glioma (LGG). We reveal that rs55705857 itself is the causal variant and is associated with molecular pathways that drive LGG. Mechanistically, we show that rs55705857 resides within a brain-specific enhancer, where the risk allele disrupts OCT2/4 binding, allowing increased interaction with the Myc promoter and increased Myc expression. Mutating the orthologous mouse rs55705857 locus accelerated tumor development in an Idh1R132H-driven LGG mouse model from 472 to 172 days and increased penetrance from 30% to 75%. Our work reveals mechanisms of the heritable predisposition to lethal glioma in ~40% of LGG patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 8
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Neoplasias Encefálicas
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Glioma
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Isocitrato Desidrogenase
Limite:
Animals
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Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2022
Tipo de documento:
Article