Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network.

Sun, Yuening; Guo, Wenjing; Guo, Yongjian; Lin, Zhangxing; Wang, Dechao; Guo, Qinglong; Zhou, Yuxin

Sun, Yuening; Guo, Wenjing; Guo, Yongjian; Lin, Zhangxing; Wang, Dechao; Guo, Qinglong; Zhou, Yuxin.

Afiliação

Sun Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, PR China.
Guo W; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, PR China.
Guo Y; School of Biopharmacy, China Pharmaceutical University, #639 Longmian Avenue, Nanjing, 211198, PR China.
Lin Z; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, PR China.
Wang D; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, PR China.
Guo Q; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: qinglongguo@hotmail.com.
Zhou Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, #24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: zyxspain@hotmail.com.

Food Chem Toxicol ; 169: 113450, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36208653

Assuntos

Antineoplásicos; Apoptose; Ácido Graxo Sintase Tipo I; Ácidos Graxos; Flavanonas; Neoplasias da Próstata; Proteína de Ligação a Elemento Regulador de Esterol 1; Humanos; Masculino; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Ácido Graxo Sintase Tipo I/metabolismo; Ácidos Graxos/metabolismo; Flavanonas/farmacologia; Metabolismo dos Lipídeos; Neoplasias da Próstata/metabolismo; Neoplasias da Próstata/patologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Proteína de Ligação a Elemento Regulador de Esterol 1/genética; Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo; Carnitina O-Acetiltransferase/metabolismo

Palavras-chave

Lipid metabolism; Mitochondrial apoptosis; Oxidative stress; Prostate cancer; Wogonin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Apoptose / Flavanonas / Proteína de Ligação a Elemento Regulador de Esterol 1 / Ácido Graxo Sintase Tipo I / Ácidos Graxos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2022 Tipo de documento: Article

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