HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2.

Sallais, Julien; Park, Chanho; Alahari, Sruthi; Porter, Tyler; Liu, Ruizhe; Kurt, Merve; Farrell, Abby; Post, Martin; Caniggia, Isabella

Sallais, Julien; Park, Chanho; Alahari, Sruthi; Porter, Tyler; Liu, Ruizhe; Kurt, Merve; Farrell, Abby; Post, Martin; Caniggia, Isabella.

Afiliação

Sallais J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Park C; Institute of Medical Sciences, and.
Alahari S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Porter T; Department of Physiology, University of Toronto, Ontario, Canada.
Liu R; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Kurt M; Department of Physiology, University of Toronto, Ontario, Canada.
Farrell A; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Post M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Caniggia I; Department of Physiology, University of Toronto, Ontario, Canada.

JCI Insight ; 7(23)2022 12 08.

Article em En | MEDLINE | ID: mdl-36227697

Assuntos

Hipertensão; Prolil Hidroxilases; Gravidez; Humanos; Feminino; Camundongos; Animais; Acriflavina; Fator 1 Induzível por Hipóxia; Placenta; Hipertensão/tratamento farmacológico

Palavras-chave

Development; Hypertension; Hypoxia; Mouse models; Reproductive Biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prolil Hidroxilases / Hipertensão Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: JCI Insight Ano de publicação: 2022 Tipo de documento: Article

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