Examination of the utility of the rat as an animal model for human anticoagulation.
Haemostasis
; 17(4): 206-10, 1987.
Article
em En
| MEDLINE
| ID: mdl-3623264
ABSTRACT
The feasibility of employing the rat as an experimental model for investigation of full-dose heparin anticoagulation was assessed. Striking similarities were found to exist between rats and humans regarding baseline-activated partial thromboplastin time (APTT) values, and dosage per kilogram of heparin required to produce an APTT value of 1 1/2-3 times normal, the clinical definition of full-dose heparinization. Based upon these similarities, it appears that the rat can effectively serve as an experimental model for investigating the effects of heparin in humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ratos
/
Coagulação Sanguínea
/
Heparina
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Haemostasis
Ano de publicação:
1987
Tipo de documento:
Article