Decreased Expression of the <i>Slc31a1</i> Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.

Haberkiewicz, Olga; Lipinski, Pawel; Starzynski, Rafal R; Jonczy, Aneta; Kurowska, Patrycja; Ogórek, Mateusz; Bednarz, Aleksandra; Herman, Sylwia; Hatala, Dawid; Grzmil, Pawel; Rajfur, Zenon; Baster, Zbigniew; Lenartowicz, Malgorzata

Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.

Haberkiewicz, Olga; Lipinski, Pawel; Starzynski, Rafal R; Jonczy, Aneta; Kurowska, Patrycja; Ogórek, Mateusz; Bednarz, Aleksandra; Herman, Sylwia; Hatala, Dawid; Grzmil, Pawel; Rajfur, Zenon; Baster, Zbigniew; Lenartowicz, Malgorzata.

Afiliação

Haberkiewicz O; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland.
Lipinski P; Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzebiec, Postepu 36A, 05-552 Magdalenka, Poland.
Starzynski RR; Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzebiec, Postepu 36A, 05-552 Magdalenka, Poland.
Jonczy A; Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzebiec, Postepu 36A, 05-552 Magdalenka, Poland.
Kurowska P; Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland.
Ogórek M; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland.
Bednarz A; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland.
Herman S; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland.
Hatala D; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland.
Grzmil P; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland.
Rajfur Z; Department of Molecular and Interfacial Biophysics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Lojasiewicza 11, 30-348 Kraków, Poland.
Baster Z; Department of Molecular and Interfacial Biophysics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Lojasiewicza 11, 30-348 Kraków, Poland.
Lenartowicz M; Cell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20824-0105, USA.

Int J Mol Sci ; 23(19)2022 Sep 28.

Article em En | MEDLINE | ID: mdl-36232742

Assuntos

Transportador de Cobre 1; Cobre; Células Epiteliais; Túbulos Renais Proximais; Síndrome dos Cabelos Torcidos; Animais; Proteínas de Transporte de Cátions/genética; Proteínas de Transporte de Cátions/metabolismo; Membrana Celular/genética; Membrana Celular/metabolismo; Cobre/metabolismo; Cobre/toxicidade; Transportador de Cobre 1/genética; Transportador de Cobre 1/metabolismo; ATPases Transportadoras de Cobre/genética; ATPases Transportadoras de Cobre/metabolismo; Citoplasma/genética; Citoplasma/metabolismo; Modelos Animais de Doenças; Células Epiteliais/metabolismo; Expressão Gênica; Túbulos Renais Proximais/metabolismo; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Síndrome dos Cabelos Torcidos/etiologia; Síndrome dos Cabelos Torcidos/genética; Síndrome dos Cabelos Torcidos/metabolismo; Camundongos; Transporte Proteico/genética; Transporte Proteico/fisiologia; RNA Mensageiro/metabolismo; Proteínas SLC31/genética; Proteínas SLC31/metabolismo

Palavras-chave

CTR1 protein; Menkes disease; Slc31a1 gene; Slc31a2 gene; copper; kidney

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cobre / Células Epiteliais / Transportador de Cobre 1 / Túbulos Renais Proximais / Síndrome dos Cabelos Torcidos Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article

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