Reno-protective effect of mangiferin against methotrexate-induced kidney damage in male rats: PPARÎ³-mediated antioxidant activity.

Attia, Seba Hassan; Elshazly, Shimaa Mustafa; Abdelaal, Mahmoud Mohamed; Soliman, Eman

Attia, Seba Hassan; Elshazly, Shimaa Mustafa; Abdelaal, Mahmoud Mohamed; Soliman, Eman.

Afiliação

Attia SH; Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Egypt.
Elshazly SM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Zagazig University, Egypt.
Abdelaal MM; Pharmacogonosy and Phytochemistry Department, Faculty of Pharmacy, Zagazig University, Egypt.
Soliman E; Pharmacology and Toxicology Department, Faculty of Pharmacy, Zagazig University, Egypt.

Saudi Pharm J ; 30(9): 1252-1261, 2022 Sep.

Article em En | MEDLINE | ID: mdl-36249937

Palavras-chave

ARE, antioxidant responsive element; BADGE, Bisphenol A diglycidyl ether; BUN, Blood urea nitrogen; COX2, cyclooxygenase 2; GSH, glutathione; GST, glutathione-S-transferase; Hmox1, hemoxygenase-1; IL-1ß, interleukin-1ß; IkBα, inhibitor of NFκB, alpha; KEAP1, Kelch-like-ECH-associated protein 1; MDA, malondialdehyde; MF, Mangiferin; MTX, methotrexate; Mangiferin; Methotrexate; NAG, N-acetyl-ß-D glucosaminidase; NFκB, nuclear factor-κB; NO, nitric oxide; Nephrotoxicity; Nrf2, nuclear factor-erythroid factor 2-related factor 2; Oxidative stress; PPARÎ³, Peroxisome proliferator-activated receptor-Ò¯; Peroxisome proliferator-activated receptor-Î³ (PPAR-Î³); ROS, reactive oxygen species; iNOS, inducible nitric oxide synthase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Saudi Pharm J Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Saudi Pharm J Ano de publicação: 2022 Tipo de documento: Article