Specialised ribosomes as versatile regulators of gene expression.
RNA Biol
; 19(1): 1103-1114, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-36255182
ABSTRACT
The ribosome has long been thought to be a homogeneous cellular machine that constitutively and globally synthesises proteins from mRNA. However, recent studies have revealed that ribosomes are highly heterogeneous, dynamic macromolecular complexes with specialised roles in translational regulation in many organisms across the kingdoms. In this review, we summarise the current understanding of ribosome heterogeneity and the specialised functions of heterogeneous ribosomes. We also discuss specialised translation systems that utilise orthogonal ribosomes.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Ribossômicas
/
Biossíntese de Proteínas
Idioma:
En
Revista:
RNA Biol
Ano de publicação:
2022
Tipo de documento:
Article