Peroxynitrite promotes immune evasion by reducing tumor antigenicity.
Cell Rep Med
; 3(10): 100787, 2022 10 18.
Article
em En
| MEDLINE
| ID: mdl-36260983
ABSTRACT
A study by Tcyganov et al.1 demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficacy preclinically.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Evasão da Resposta Imune
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Cell Rep Med
Ano de publicação:
2022
Tipo de documento:
Article