A signature of structural MRI features at 3 Tesla allows an accurate characterization of orbital cavernous venous malformation.
Eur Radiol
; 33(3): 2149-2159, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36264311
ABSTRACT
OBJECTIVES:
To differentiate OCVM from other orbital lesions using structural MRI.METHODS:
This IRB-approved a historical-prospective cohort single-center analysis of a prospective cohort that included consecutive adult patients presenting with an orbital lesion undergoing a 3T MRI before surgery from December 2015 to May 2021. Two readers blinded to all data read all MRIs assessing structural MRI characteristics. A univariate analysis followed by a stepwise multivariate analysis identified structural MRI features showing the highest sensitivity and specificity when diagnosing OCVM.RESULTS:
One hundred ninety-one patients with 30/191 (16%) OCVM and 161/191 (84%) other orbital lesions were included. OCVM were significantly more likely to present with a higher signal intensity than that of the cortex on T2WI 26/29 (89.7%) versus 28/160 (17.5%), p < 0.001, or with a chemical shift artifact (CSA) 26/29 (89.7%) versus 16/155 (10.3%), p < 0.001, or to present with a single starting point of enhancement, as compared to other orbital lesions 18/29 (62.1%) versus 4/159 (2.5%), p = 0.001. The step-wise analysis identified 2 signatures increasing performances. Signature 1 combined a higher signal intensity than that of the cortex on T2WI and a CSA. Signature 2 included these two features and the presence of a single starting point of enhancement. Sensitivity, specificity, and accuracy were 0.83, 0.94, and 0.92 for signature 1 and 0.97, 0.93, and 0.93 for signature 2, respectively.CONCLUSION:
Structural MRI yields high sensitivity and specificity when diagnosing OCVM. KEY POINTS ⢠Structural MRI shows high sensitivity and specificity when diagnosing orbital cavernous venous malformation. ⢠We identified two signatures combining structural MRI features which might be used easily in routine clinical practice. ⢠The combination of higher signal intensity of the lesion as compared to the cortex on T2WI and of a chemical shift artifact yields a sensitivity and specificity of 0.83 and 0.94 for the diagnosis of orbital cavernous venous malformation, respectively.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Orbitárias
/
Malformações Vasculares
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Eur Radiol
Ano de publicação:
2023
Tipo de documento:
Article