Efforts toward the Total Synthesis of Elisabethin A.
J Org Chem
; 87(22): 15333-15349, 2022 11 18.
Article
em En
| MEDLINE
| ID: mdl-36283031
ABSTRACT
We describe our efforts toward the total synthesis of the natural product elisabethin A. The first route was guided by the proposed biosynthesis, assembling the 6,6-ring system before forming the five-membered ring including the quaternary carbon. The second approach includes a high yielding cyclization under Mitsunobu conditions as a key step. It allowed the preparation of an unusual and highly functionalized bicyclic 6,5-spiro compound. Both routes share a common advanced precursor obtained from an "underdeveloped" Claisen rearrangement of an aryl dienyl ether.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
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Diterpenos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article