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Recent Insights into Insect Olfactory Receptors and Odorant-Binding Proteins.
Ha, Tal Soo; Smith, Dean P.
Afiliação
  • Ha TS; Department of Biomedical Science, College of Natural Science, Daegu University, Gyeongsan 38453, Gyeongsangbuk-do, Korea.
  • Smith DP; Departments of Pharmacology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Insects ; 13(10)2022 Oct 13.
Article em En | MEDLINE | ID: mdl-36292874
Human and insect olfaction share many general features, but insects differ from mammalian systems in important ways. Mammalian olfactory neurons share the same overlying fluid layer in the nose, and neuronal tuning entirely depends upon receptor specificity. In insects, the olfactory neurons are anatomically segregated into sensilla, and small clusters of olfactory neurons dendrites share extracellular fluid that can be independently regulated in different sensilla. Small extracellular proteins called odorant-binding proteins are differentially secreted into this sensillum lymph fluid where they have been shown to confer sensitivity to specific odorants, and they can also affect the kinetics of the olfactory neuron responses. Insect olfactory receptors are not G-protein-coupled receptors, such as vertebrate olfactory receptors, but are ligand-gated ion channels opened by direct interactions with odorant molecules. Recently, several examples of insect olfactory neurons expressing multiple receptors have been identified, indicating that the mechanisms for neuronal tuning may be broader in insects than mammals. Finally, recent advances in genome editing are finding applications in many species, including agricultural pests and human disease vectors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Insects Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Insects Ano de publicação: 2022 Tipo de documento: Article