Sex Modifies the Associations of APOEÉ4 with Neuropsychiatric Symptom Burden in Both At-Risk and Clinical Cohorts of Alzheimer's Disease.
J Alzheimers Dis
; 90(4): 1571-1588, 2022.
Article
em En
| MEDLINE
| ID: mdl-36314203
ABSTRACT
BACKGROUND:
Recent work suggests that APOEÉ4/4 females with Alzheimer's disease (AD) are more susceptible to developing neuropsychiatric symptoms (NPS).OBJECTIVE:
To examine the interaction of sex and APOEÉ4 status on NPS burden using two independent cohorts 1) patients at risk for AD with mild cognitive impairment and/or major depressive disorder (nâ=â252) and 2) patients with probable AD (nâ=â7,261).METHODS:
Regression models examined the interactive effects of sex and APOEÉ4 on the number of NPS experienced and NPS Severity. APOEÉ3/4 and APOEÉ4/4 were pooled in the at-risk cohort due to the sample size.RESULTS:
In the at-risk cohort, there was a significant sex*APOEÉ4 interaction (pâ=â0.007) such that the association of APOEÉ4 with NPS was greater in females than in males (incident rate ratio (IRR)â=â2.0). APOEÉ4/4 females had the most NPS (meanâ=â1.9) and the highest severity scores (meanâ=â3.5) of any subgroup. In the clinical cohort, APOEÉ4/4 females had significantly more NPS (IRRâ=â1.1, pâ=â0.001, meanâ=â3.1) and higher severity scores (bâ=â0.31, pâ=â0.015, meanâ=â3.7) than APOEÉ3/3 females (meanNPSâ=â2.9, meanSeverityâ=â3.3). No association was found in males.CONCLUSION:
Our study suggests that sex modifies the association of APOEÉ4 on NPS burden. APOEÉ4/4 females may be particularly susceptible to increased NPS burden among individuals with AD and among individuals at risk for AD. Further investigation into the mechanisms behind these associations are needed.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo Maior
/
Doença de Alzheimer
/
Disfunção Cognitiva
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
/
Male
Idioma:
En
Revista:
J Alzheimers Dis
Ano de publicação:
2022
Tipo de documento:
Article