Copper(I)-Catalyzed Three-Component Selenosulfonation of Maleimides with Sulfonyl Hydrazides and Diselenides via Radical Relay.
J Org Chem
; 87(22): 15661-15669, 2022 11 18.
Article
em En
| MEDLINE
| ID: mdl-36317696
ABSTRACT
By employing Cu(CH3CN)4PF6 as the catalyst and tert-butyl hydroperoxide as the oxidant, we realized a three-component radical selenosulfonation of substituted maleimides, sulfonyl hydrazides, and diphenyl diselenides, providing a series of 3,4-selenosulfonylated succinimides in moderate to good yields. This reaction features broad substrate scopes, high functional-group tolerability, and feasibility of gram-scale synthesis, enabling one-step construction of C-SO2 and C-Se bonds under mild reaction conditions. Preliminary mechanistic studies support the free-radical-induced pathway.
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MEDLINE
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Cobre
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Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article