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Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death.
Chang, Shih Chieh; Gopal, Pooja; Lim, Shuhui; Wei, Xiaona; Chandramohan, Arun; Mangadu, Ruban; Smith, Jeffrey; Ng, Simon; Gindy, Marian; Phan, Uyen; Henry, Brian; Partridge, Anthony William.
Afiliação
  • Chang SC; Quantitative Biosciences, MSD, Singapore 119077, Singapore.
  • Gopal P; Quantitative Biosciences, MSD, Singapore 119077, Singapore.
  • Lim S; Quantitative Biosciences, MSD, Singapore 119077, Singapore.
  • Wei X; Scientific Informatics, MSD, Singapore 119077, Singapore.
  • Chandramohan A; Quantitative Biosciences, MSD, Singapore 119077, Singapore.
  • Mangadu R; Discovery Oncology, Merck & Co., Inc., South San Francisco, CA, USA.
  • Smith J; Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Ng S; Quantitative Biosciences, MSD, Singapore 119077, Singapore.
  • Gindy M; Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Phan U; Discovery Oncology, Merck & Co., Inc., South San Francisco, CA, USA.
  • Henry B; Quantitative Biosciences, MSD, Singapore 119077, Singapore.
  • Partridge AW; Quantitative Biosciences, MSD, Singapore 119077, Singapore. Electronic address: awpartridge2@gmail.com.
Cell Chem Biol ; 29(11): 1601-1615.e7, 2022 11 17.
Article em En | MEDLINE | ID: mdl-36318925
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases / Lipossomos Idioma: En Revista: Cell Chem Biol Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases / Lipossomos Idioma: En Revista: Cell Chem Biol Ano de publicação: 2022 Tipo de documento: Article