Psychiatric Disorder Incidence Among Adolescents and Young Adults Aged 15-39 With Cancer: Population-Based Cohort.
JNCI Cancer Spectr
; 6(6)2022 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-36321955
ABSTRACT
BACKGROUND:
Adolescent and young adult (AYA) cancer survivors face physical and psychological sequelae related to having cancer decades after treatment completion. It is unclear if AYA cancer survivors are at increased risk for late psychiatric disorders.METHODS:
We used the Alberta AYA Cancer Survivor Study that includes 5-year survivors of cancer diagnosed at age 15-39 years during 1991 to 2013. The primary outcome was incidence of psychiatric disorder (composite outcome) including anxiety, depressive, trauma- and stressor-related, psychotic, and substance use disorders that were identified using coding algorithms for administrative health databases. A validated coding algorithm identified people who experienced a suicide attempt or event of self-harm. Secondary outcomes were incidences of diagnoses by type of psychiatric disorder.RESULTS:
Among 12â116 AYA 5-year cancer survivors (n = 4634 [38%] males; n = 7482 [62%] females), 7426 (61%; n = 2406 [32%] males; n = 5020 [68%] females) were diagnosed with at least 1 of 5 psychiatric disorders occurring at least 3 years after cancer diagnosis. Survivors of all cancer types were most often diagnosed with anxiety (males 39.0%, 95% confidence interval [CI] = 37.6% to 40.4%; females 54.5%, 95% CI = 53.3% to 55.6%), depressive (males 32.7%, 95% CI = 31.3% to 34.0%; females 47.0%, 95% CI = 45.8% to 48.1%), and trauma- and stressor-related disorders (males 13.5%, 95% CI =12.5% to 14.5%; females 22.5%, 95% CI = 21.6% to 23.5%).CONCLUSIONS:
Anxiety, depressive, and trauma- and stressor-related disorders are common among 5-year survivors of AYA cancer. Primary, secondary, or tertiary preventive strategies for AYAs diagnosed with cancer, particularly at an early age, are needed to mitigate risk of potentially severe outcomes because of psychiatric disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sobreviventes de Câncer
/
Transtornos Mentais
/
Neoplasias
Tipo de estudo:
Incidence_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
JNCI Cancer Spectr
Ano de publicação:
2022
Tipo de documento:
Article