Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization.

Camviel, Nicolas; Wolf, Benita; Croce, Giancarlo; Gfeller, David; Zoete, Vincent; Arber, Caroline

Camviel, Nicolas; Wolf, Benita; Croce, Giancarlo; Gfeller, David; Zoete, Vincent; Arber, Caroline.

Afiliação

Camviel N; Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Wolf B; Ludwig Institute for Cancer Research Lausanne Branch, Lausanne, Switzerland.
Croce G; Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Gfeller D; Ludwig Institute for Cancer Research Lausanne Branch, Lausanne, Switzerland.
Zoete V; Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Arber C; Ludwig Institute for Cancer Research Lausanne Branch, Lausanne, Switzerland.

J Immunother Cancer ; 10(11)2022 11.

Article em En | MEDLINE | ID: mdl-36323436

Assuntos

Mieloma Múltiplo; Receptores de Antígenos Quiméricos; Anticorpos de Cadeia Única; Camundongos; Animais; Humanos; Antígeno de Maturação de Linfócitos B/genética; Antígeno de Maturação de Linfócitos B/metabolismo; Ligantes; Trogocitose; Recidiva Local de Neoplasia/metabolismo; Linfócitos T

Palavras-chave

T-lymphocytes; cell engineering; hematologic neoplasms; immunotherapy; receptors, chimeric antigen

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos de Cadeia Única / Receptores de Antígenos Quiméricos / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google