Osteopontin expression in the invasive front stroma of colorectal adenocarcinoma is associated with tumor budding and prognosis.
Pathol Res Pract
; 240: 154190, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36332325
ABSTRACT
BACKGROUND:
Tumor budding (TB) is an important prognostic factor in colorectal carcinoma (CRC). Osteopontin (OPN) functions in various processes such as immune response, migration and invasion, angiogenesis, epithelial-mesenchymal transition (EMT) and metastasis. However, the involvement of OPN and CD44v6, which is a receptor for OPN, in TB has not been clarified. Therefore, we examined the relationship of OPN with TB in CRC and compared the clinicopathological features.METHODS:
We investigated the expression of OPN and CD44v6 in 83 cases of CRC by immunostaining and analyzed the clinicopathological features.RESULTS:
OPN expression was observed mostly in the cytoplasm of stromal cells such as macrophages and fibroblasts, and rarely in cancer cells. There was a significant correlation between OPN positivity and the degree of differentiation at the invasive front and TB grade. CD44v6 was positive in cancer cells in 72 cases (86.7 %) and negative in 11 cases (13.3 %). A statistically significant effect on overall survival (OS) was identified between the OPN-positive group [median OS 1586 (range, 30-2749) days] and the OPN-negative group [median OS 1901 (range, 8-2665) days] (log-rank test, p = 0.011).CONCLUSIONS:
OPN analysis in CRC stromal cells may have prognostic implications.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Adenocarcinoma
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Pathol Res Pract
Ano de publicação:
2022
Tipo de documento:
Article