Maternal colonization with extended-spectrum ß-lactamase-producing Enterobacteriaceae in term versus preterm pregnancies.
Int J Gynaecol Obstet
; 161(2): 447-454, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36334053
ABSTRACT
OBJECTIVES:
To examine the prevalence and risk factors of extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-E) colonization among women who delivered preterm and at term.METHODS:
A prospective observational study of maternal ESBL-E rectovaginal colonization in threatened preterm labor and low-risk term pregnancies was conducted between March 2017 and August 2021 at the Galilee Medical Center, Israel. Obstetric and neonatal complications were compared between colonized and non-colonized mothers and neonates.RESULTS:
ESBL-E colonization was similar in the preterm (n = 202) and term (n = 172) groups 14.4% and 16.9%, respectively (P = 0.567). The maternal-neonatal transmission rate was higher in the preterm than the term group but the difference was not statistically significant 42.1% and 22.2%, respectively (P = 0.42). Prematurity was a risk factor of neonatal ESBL-E colonization (odds ratio 1.33, 95% confidence interval 1.01-1.75, P = 0.041). ESBL-E-colonized preterm infants were delivered at an earlier gestational age and were more likely to have complications. Maternal ESBL-E colonization and transmission were more prevalent in pregnancies complicated by threatened preterm labor or premature rupture of membranes than in term pregnancies.CONCLUSIONS:
These findings emphasize the need for further research on the cost-effectiveness of screening for maternal ESBL-E colonization in preterm labor, to prevent neonatal infectious complications. CLINICALTRIALS gov identifier NCT03251885.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Infecções por Enterobacteriaceae
/
Trabalho de Parto Prematuro
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Revista:
Int J Gynaecol Obstet
Ano de publicação:
2023
Tipo de documento:
Article