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Prospective associations of circulating thrombospondin-2 level with heart failure hospitalization, left ventricular remodeling and diastolic function in type 2 diabetes.
Lee, C H; Wu, M Z; Lui, Dtw; Fong, Chy; Ren, Q W; Yu, S Y; Yuen, Mma; Chow, W S; Huang, J Y; Xu, A; Yiu, K H; Lam, Ksl.
Afiliação
  • Lee CH; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Wu MZ; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Lui D; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Fong C; Division of CardiologyDepartment of Medicine, the University of Hong Kong-Shenzhen Hospital, Shen Zhen, China.
  • Ren QW; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Yu SY; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Yuen M; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Chow WS; Division of CardiologyDepartment of Medicine, the University of Hong Kong-Shenzhen Hospital, Shen Zhen, China.
  • Huang JY; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Xu A; Division of CardiologyDepartment of Medicine, the University of Hong Kong-Shenzhen Hospital, Shen Zhen, China.
  • Yiu KH; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
  • Lam K; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
Cardiovasc Diabetol ; 21(1): 231, 2022 11 05.
Article em En | MEDLINE | ID: mdl-36335340
BACKGROUND: Circulating thrombospondin-2 (TSP2) levels were associated with the development of heart failure (HF) in recent studies. However, these studies included only a minority of patients with type 2 diabetes, which is associated with an increased HF risk. As hyperglycemia induces TSP2 expression and its tissue expression increases in type 2 diabetes, we investigated the prospective association of circulating TSP2 with incident HF hospitalization (HHF), and its associations with longitudinal changes of echocardiographic parameters in type 2 diabetes. METHODS: Baseline serum TSP2 levels were measured in 4949 patients with type 2 diabetes to determine its association with incident HHF using multivariable Cox regression analysis. In the echocardiographic study, baseline serum TSP2 levels were measured in another 146 patients with type 2 diabetes but without cardiovascular diseases who underwent detailed transthoracic echocardiography at baseline and after 1 year. RESULTS: Over a median follow-up of 7.8 years, 330 of 4949 patients (6.7%) developed incident HHF. Baseline serum TSP2 levels were independently associated with the development of HHF (HR 1.31, 95%CI 1.06-1.62, p = 0.014) after adjustments for baseline conventional cardiovascular risk factors, atrial fibrillation, estimated glomerular filtration rate, albuminuria and high-sensitivity C-reactive protein level, use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, loop-diuretics, aspirin, insulin, metformin and sodium-glucose co-transporter 2 inhibitors. Moreover, baseline serum TSP2 levels were independently associated with increase in average E/e' and left atrial volume index (p = 0.04 and < 0.01, respectively). CONCLUSION: Serum TSP2 levels were independently associated with both incident HHF and deterioration in diastolic function in type 2 diabetes. TRIAL REGISTRATION: Not Applicable.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores do Transportador 2 de Sódio-Glicose / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cardiovasc Diabetol Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores do Transportador 2 de Sódio-Glicose / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cardiovasc Diabetol Ano de publicação: 2022 Tipo de documento: Article