Hippocampal Galectin-3 knockdown alleviates lipopolysaccharide-induced neurotoxicity and cognitive deficits by inhibiting TLR4/NF-ÐºB signaling in aged mice.

Chen, Fang; Wu, Xiaofeng; Yang, Jiayong; Yu, Xuben; Liu, Bili; Yan, Zhiwen

Chen, Fang; Wu, Xiaofeng; Yang, Jiayong; Yu, Xuben; Liu, Bili; Yan, Zhiwen.

Afiliação

Chen F; Department of Pharmacy, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.
Wu X; Department of Pharmacy, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.
Yang J; Department of Pharmacy, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.
Yu X; Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Liu B; Department of Pharmacy, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China. Electronic address: 3079158007@qq.com.
Yan Z; Department of Pharmacy, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China. Electronic address: yzwfirst@xmu.edu.cn.

Eur J Pharmacol ; 936: 175360, 2022 Dec 05.

Article em En | MEDLINE | ID: mdl-36336009

Assuntos

Doença de Alzheimer; Síndromes Neurotóxicas; Animais; Camundongos; Receptor 4 Toll-Like/genética; NF-kappa B; Lipopolissacarídeos/toxicidade; Galectina 3/genética; Galectinas; Hipocampo; Cognição

Palavras-chave

Alzheimer's disease; Cognitive deficits; Galectin-3; Lipopolysaccharide; Neuroinflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Neurotóxicas / Doença de Alzheimer Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2022 Tipo de documento: Article

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