Periocular Merkel Cell Carcinoma - An Overview of Clinical Aspects and Current Treatment Options. / Das periokuläre Merkel-Zell-Karzinom eine Übersicht klinischer Aspekte und aktueller Therapieoptionen.
Klin Monbl Augenheilkd
; 240(1): 24-32, 2023 Jan.
Article
em En, De
| MEDLINE
| ID: mdl-36368663
ABSTRACT
Merkel cell carcinoma (MCC) is a rare but highly aggressive and rapidly expanding malignant skin tumor. It affects the periocular region in approximately 10% of cases. The current treatment recommendation for resectable non-metastatic MCC comprises total surgical excision; however, lymph node or distant metastases are often already present by the time of the diagnosis. Since an immune checkpoint inhibitor therapy with avelumab was first approved for MCC in 2016, there has been considerable improvement in mean survival compared to cytostatic therapy; at the same time, there has been a reduction in serious treatment-associated adverse events. Other immune checkpoint inhibitors are currently still in clinical trials, with very promising initial results. Because of the complexity of the diagnosis, treatment, and prognosis, it is essential that MCC patients receive interdisciplinary care in a specialized center including consultation with a tumor review board.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma de Célula de Merkel
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
De
/
En
Revista:
Klin Monbl Augenheilkd
Ano de publicação:
2023
Tipo de documento:
Article