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Single and repeated bisphenol A treatment induces ROS, Aß and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death.
Flores, Andrea; Moyano, Paula; Sola, Emma; García, José Manuel; García, Jimena; Anadon, María José; Frejo, María Teresa; Naval, Maria Victoria; Fernadez, Maria de la Cabeza; Pino, Javier Del.
Afiliação
  • Flores A; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
  • Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: pmoyanocires@ucm.es.
  • Sola E; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: esola@ucm.es.
  • García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
  • García J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
  • Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
  • Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
  • Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28040, Madrid, Spain.
  • Fernadez MC; Department of Chemistry in Pharmaceutical Sciences, Pharmacy School, Complutense University of Madrid, 28041, Madrid, Spain.
  • Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: jdelpino@pdi.ucm.es.
Food Chem Toxicol ; 170: 113500, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36374790
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Insulinas Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Insulinas Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2022 Tipo de documento: Article