Effect of histone deacetylase inhibitor (vorinostat) on new-onset diabetes induced by tacrolimus.

Bakhdar, Fatmah A; Abdel Kawy, Hala S; Magadmi, Rania M; El-Kordy, Eman A; Alamri, Abdulhakeem S

Bakhdar, Fatmah A; Abdel Kawy, Hala S; Magadmi, Rania M; El-Kordy, Eman A; Alamri, Abdulhakeem S.

Afiliação

Bakhdar FA; Pharmacology Department, Faculty of Medicine, King Abdulaziz University, KSA.
Abdel Kawy HS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Umm Al-Qura University, KSA.
Magadmi RM; Pharmacology Department, Faculty of Medicine, King Abdulaziz University, KSA.
El-Kordy EA; Pharmacology Department, Faculty of Medicine, King Abdulaziz University, KSA.
Alamri AS; Anatomy Department, Faculty of Medicine, Imam Mohammad Ibn Saud Islamic University, KSA.

J Taibah Univ Med Sci ; 18(1): 9-18, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36398015

Palavras-chave

Anti-inflammatory; Anti-oxidant; BUN, blood urea nitrogen; DMSO, dimethyl sulfoxide solution; ELISA, enzyme linked immunosorbent assay; FGT, fast glucose test; GSH, glutathione; HDACi, histone deacetylase inhibitor; HOMA-IR, homeostatic model assessment for insulin resistance index; Histone deacetylases inhibitors; IL-1ß, interleukin-1 beta; IP, intraperitoneal; NADPH-oxidase, nicotinamide adenine dinucleotide phosphate hydrogen oxidase enzyme; NODAT, new-onset diabetes after transplantation; New-onset diabetes after transplantation; PO, oral gavage; TNF-α, tumor necrosis factor-α; Tacro, tacrolimus; Tacrolimus; Vorino, vorinostat; Vorinostat

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Taibah Univ Med Sci Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Taibah Univ Med Sci Ano de publicação: 2023 Tipo de documento: Article