SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPß/TNF-&#945; signaling axis in rheumatoid arthritis.

Teng, Xiu; Mou, Da-Chao; Li, Hui-Fang; Jiao, Ling; Wu, Sha-Sha; Pi, Jin-Kui; Wang, Yan; Zhu, Meng-Li; Tang, Meng; Liu, Yi

SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPß/TNF-α signaling axis in rheumatoid arthritis.

Teng, Xiu; Mou, Da-Chao; Li, Hui-Fang; Jiao, Ling; Wu, Sha-Sha; Pi, Jin-Kui; Wang, Yan; Zhu, Meng-Li; Tang, Meng; Liu, Yi.

Afiliação

Teng X; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, 610041, China. tengxiu@wchscu.cn.
Mou DC; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. tengxiu@wchscu.cn.
Li HF; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jiao L; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wu SS; Core Facilities of West China Hospital, Sichuan University, Chengdu, 610041, China.
Pi JK; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wang Y; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhu ML; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tang M; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Liu Y; Core Facilities of West China Hospital, Sichuan University, Chengdu, 610041, China.

Mol Med ; 28(1): 135, 2022 11 18.

Article em En | MEDLINE | ID: mdl-36401167

Assuntos

Artrite Reumatoide; Fator de Necrose Tumoral alfa; Humanos; Camundongos; Animais; Linfócitos T CD4-Positivos/metabolismo; Receptores de Interleucina-1/genética; Receptores de Interleucina-1/metabolismo; Transdução de Sinais/fisiologia; Artrite Reumatoide/genética

Palavras-chave

CCAAT/enhancer-binding protein ß (C/EBP ß); CD4 T cells; Rheumatoid arthritis (RA); Single immunoglobulin interleukin-1 receptor (SIGIRR); Tumor necrosis factor (TNF)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Fator de Necrose Tumoral alfa Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Med Ano de publicação: 2022 Tipo de documento: Article

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