Paeoniflorin protects NOD mice from T1D through regulating gut microbiota and TLR4 mediated myD88/TRIF pathway.

Luo, Cheng; Yang, Danyi; Hou, Can; Tan, Tingting; Chao, Chen

Luo, Cheng; Yang, Danyi; Hou, Can; Tan, Tingting; Chao, Chen.

Afiliação

Luo C; Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, PR China.
Yang D; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, PR China; Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan Province, PR China.
Hou C; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, PR China.
Tan T; Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha 410008, Hunan Province, PR China.
Chao C; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, PR China. Electronic address: chaochen@csu

Exp Cell Res ; 422(1): 113429, 2023 01 01.

Article em En | MEDLINE | ID: mdl-36402426

Assuntos

Diabetes Mellitus Experimental; Microbioma Gastrointestinal; Animais; Camundongos; Proteínas Adaptadoras de Transporte Vesicular/genética; Diabetes Mellitus Tipo 1/tratamento farmacológico; Diabetes Mellitus Tipo 1/microbiologia; Microbioma Gastrointestinal/efeitos dos fármacos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos NOD; Fator 88 de Diferenciação Mieloide/metabolismo; Transdução de Sinais; Receptor 4 Toll-Like/efeitos dos fármacos; Receptor 4 Toll-Like/metabolismo; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Experimental/microbiologia

Palavras-chave

Gut microbiota; NOD mice; Paeoniflorin; TLR4/myD88/TRIF; Type 1 diabetes mellitus

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Exp Cell Res Ano de publicação: 2023 Tipo de documento: Article

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