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The hemoglobin glycation index predicts the risk of adverse cardiovascular events in coronary heart disease patients with type 2 diabetes mellitus.
Xu, Shuai; Qin, Zhen; Yuan, Ruixia; Cui, Xiaolin; Zhang, Li; Bai, Jing; Liu, Gangqiong; Wang, Zeyu; Yu, Fengyi; Lv, Yan; Zhang, Jinying; Tang, Junnan.
Afiliação
  • Xu S; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Qin Z; Henan Province Key Laboratory of Cardiac Injury and Repair, Zhengzhou, China.
  • Yuan R; Henan Province Clinical Research Center for Cardiovascular Diseases, Zhengzhou, China.
  • Cui X; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Zhang L; Henan Province Key Laboratory of Cardiac Injury and Repair, Zhengzhou, China.
  • Bai J; Henan Province Clinical Research Center for Cardiovascular Diseases, Zhengzhou, China.
  • Liu G; Clinical Big Data Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Wang Z; School of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Yu F; Department of Bone and Joint, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Lv Y; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Zhang J; Henan Province Key Laboratory of Cardiac Injury and Repair, Zhengzhou, China.
  • Tang J; Henan Province Clinical Research Center for Cardiovascular Diseases, Zhengzhou, China.
Front Cardiovasc Med ; 9: 992252, 2022.
Article em En | MEDLINE | ID: mdl-36407464
Background: Previous studies have shown that the hemoglobin glycation index (HGI) can be used as a predictor of diabetic complications. However, limited information is currently available to indicate the correlation between HGI and comorbidity of coronary heart disease (CHD) and diabetes. This study aimed to evaluate the potential of HGI to predict major adverse cardiovascular events (MACEs) in CHD patients with type 2 diabetes mellitus (T2DM) undergoing percutaneous coronary intervention (PCI). Materials and methods: A total of 918 CHD patients with T2DM were enrolled in a 3-year retrospective cohort study, from December 2017 to December 2020 at the First Affiliated Hospital of Zhengzhou University. Data including fasting blood glucose (FPG/FBG) and glycated hemoglobin A1c (HbA1c) were collected. HGI was calculated as actual measured HbA1c minus predicted HbA1c. Three groups were further divided based on the levels of HGI, including low, medium, and high levels. Result: Kaplan Meier analysis indicated that elevated HGI was strongly associated with the occurence of MACE (log-rank P < 0.001). Multivariate Cox regression analysis revealed that elevated HGI was an independent risk factor for incident MACE in CHD patients with T2DM [adjusted hazard ratio (HR): 1.473; 95% confidence interval (CI): 1.365-1.589, P < 0.001]. Conclusions: Hemoglobin glycation index is an independent predictor of MACE events in CHD patients with T2DM. High HGI indicates a higher risk of MACE occurrence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Ano de publicação: 2022 Tipo de documento: Article