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Micro lesion effect of pallidal deep­brain stimulation for meige syndrome.
Liu, Jiayu; Ding, Hu; Xu, Ke; Wang, Dongliang; Ouyang, Jia; Liu, Zhi; Liu, Ruen.
Afiliação
  • Liu J; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China.
  • Ding H; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China.
  • Xu K; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China.
  • Wang D; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China.
  • Ouyang J; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China.
  • Liu Z; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China.
  • Liu R; Department of Neurosurgery, Peking University People's Hospital, 11Th Xizhimen South St., Beijing, 100044, China. liuruen@pku.edu.cn.
Sci Rep ; 12(1): 19980, 2022 11 21.
Article em En | MEDLINE | ID: mdl-36411289
ABSTRACT
To analyse the microlesion effect (MLE) in the globus pallidus interna (GPi) of deep brain stimulation (DBS) in patients with Meige syndrome. Thirty-two patients with primary Meige syndrome who underwent GPi-DBS in this study. Burke-Fahn-Marsden Dystonia Rating Scale scores (BFMDRS-M) were obtained for the evaluation of clinical symptoms at 3 days before DBS (baseline), 24 h after DBS surgery, once weekly for 1 month until electrical stimulation, 6 months postoperatively and 12 months after surgery. Twenty-seven patients had MLE after GPi-DBS. The mean time of BFMDRS-M scores maximal improvement from MLE was 35.9 h postoperatively (range, 24-48 h), and the mean scores improved by 49.35 ± 18.16%. At 12 months after surgery, the mean BFMDRS-M scores improved by 50.28 ± 29.70%. There was a positive correlation between the magnitude of MLE and the motor score at 12 months after GPi-DBS (R2 = 0.335, p < 0.05). However, there was no correlation between the duration of MLE and DBS improvement. Most Meige syndrome patients who underwent GPi-DBS and had MLE benefited from MLE. For Meige syndrome, MLE might be a predictive factor for patient clinical symptom improvement from DBS.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Encefálica Profunda / Distonia / Síndrome de Meige Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Encefálica Profunda / Distonia / Síndrome de Meige Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article