Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome.
Molecules
; 27(22)2022 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-36431828
ABSTRACT
The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. This review highlights a number of dietary compounds that positively affect the maintenance of the circadian clock. Notably the polymethoxyflavone nobiletin has shown some encouraging results in pre-clinical experiments. Although many more experiments are needed to fully elucidate its exact mechanism of action, it is a promising candidate with potential as a chronotherapeutic agent.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citrus
/
Síndrome Metabólica
/
Flavonas
Limite:
Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2022
Tipo de documento:
Article