Chemical Constituents of the Deep-Sea-Derived Fungus Cladosporium oxysporum 170103 and Their Antibacterial Effects.
Chem Biodivers
; 19(12): e202200963, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36436828
ABSTRACT
The Cladosporium fungi, one of the largest genera of dematiaceous hyphomycetes, could produce various bioactive secondary metabolites. From the AcOEt-soluble extract of Cladosporium oxysporum 170103, three new secopatulolides (1-3) and thirteen known compounds (4-16) were obtained. Their structures were established by detailed analysis of the NMR and HR-ESI-MS data. All sixteen compounds were tested for antibacterial activity against Vibrio parahemolyticus, ergosterol (10) presented moderate effect with the minimum inhibitory concentration (MIC) of 32â
µM. It can destruct the membrane integrity of Vibrio parahemolyticus to change the cell shape.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cladosporium
/
Antibacterianos
Idioma:
En
Revista:
Chem Biodivers
Ano de publicação:
2022
Tipo de documento:
Article