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Association of CYP19A1 Gene, Plasma Zinc, and Urinary Zinc with the Risk of Type 2 Diabetes Mellitus in a Chinese Population.
Wang, Xuexiu; Liang, Yujian; Liu, Qiumei; Cai, Jiansheng; Tang, Xu; Liu, Shuzhen; Zhang, Junling; Xu, Min; Wei, Chunmei; Mo, Xiaoting; Wei, Yanfei; Lin, Yinxia; Huang, Shenxiang; Mai, Tingyu; Tan, Dechan; Luo, Tingyu; Gou, Ruoyu; Qin, Jian; Zhang, Zhiyong.
Afiliação
  • Wang X; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Liang Y; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Liu Q; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Cai J; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Tang X; Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
  • Liu S; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Zhang J; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Xu M; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Wei C; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Mo X; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Wei Y; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Lin Y; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Huang S; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Mai T; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
  • Tan D; Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, China.
  • Luo T; Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, China.
  • Gou R; Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, China.
  • Qin J; Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, China.
  • Zhang Z; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China. qinjian@gxmu.edu.cn.
Biol Trace Elem Res ; 201(9): 4205-4215, 2023 Sep.
Article em En | MEDLINE | ID: mdl-36441497
To explore the effects of CYP19A1 gene polymorphisms, plasma zinc, and urinary zinc levels and their interactions on type 2 diabetes mellitus (T2DM) in residents of Gongcheng County, Guangxi, China. The case-control study was used for the investing. The MassARRAY System was applied to genotype the CYP19A1 genes rs752760, rs10046, rs10459592, and rs700518 in 540 study subjects. Plasma and urinary zinc concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS). Conditional logistic regression showed that rs752760 and plasma zinc were associated with T2DM risks with ORs of 0.593 (95% CI: 0.371-0.948) and 0.563 (95% CI: 0.356-0.889), respectively. Unconditional logistic regression analysis showed an association between urinary zinc levels and the risk of T2DM as well, with an OR of 0.352 (95% CI: 0.212-0.585). The results of the multiplicative interaction model showed that the rs752760 T allele was associated with a significantly reduced risk of T2DM with moderate/low plasma zinc levels, with ORs of 0.340 (95% CI: 0.161-0.715) and 0.583 (95% CI: 0.346-0.981), respectively, and the rs752760 T allele was also associated with a significantly decreased risk of T2DM with moderate/low urinary zinc levels, with ORs of 0.358 (95% CI: 0.201-0.635) and 0.321 (95% CI: 0.183-0.562), respectively. CYP19A1 rs752760 T allele and moderate/low plasma/urinary zinc levels reduce the risk of T2DM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Biol Trace Elem Res Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Biol Trace Elem Res Ano de publicação: 2023 Tipo de documento: Article