A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b.

Saito, Shunsuke; Ishikawa, Tokiro; Ninagawa, Satoshi; Okada, Tetsuya; Mori, Kazutoshi

Saito, Shunsuke; Ishikawa, Tokiro; Ninagawa, Satoshi; Okada, Tetsuya; Mori, Kazutoshi.

Afiliação

Saito S; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Ishikawa T; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Ninagawa S; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Okada T; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Mori K; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.

Elife ; 112022 11 29.

Article em En | MEDLINE | ID: mdl-36444643

Assuntos

Doença dos Neurônios Motores; Neuroblastoma; Humanos; Animais; Camundongos; Cálcio; Neuroblastoma/genética; Apoptose; Mutação

Palavras-chave

ER stress; UPR; apoptosis; calcium pump; cell biology; human; neurodegenerative disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença dos Neurônios Motores / Neuroblastoma Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2022 Tipo de documento: Article

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