Granulocyte colony stimulating factor versus human chorionic gonadotropin for recurrent implantation failure in intra cytoplasmic sperm injection: a randomized clinical trial.
BMC Pregnancy Childbirth
; 22(1): 881, 2022 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-36447142
ABSTRACT
BACKGROUND:
Repeated implantation failure (RIF) is defined as the case whereby the transferred embryos fail to implant after several attempts of In vitro fertilization (IVF) which causes a profound impact on the quality of life and financial burden. Some clinical studies have confirmed that Granulocyte colony-stimulating factor (G-CSF) and human chorionic gonadotropin (HCG) can improve pregnancy outcomes and implantation rates. Hence, our study aims to compare the efficacy of G-CSF and HCG on pregnancy outcomes in RIF women who undergo intra-cytoplasmic sperm injection (ICSI).METHODS:
This randomized, single-blinded study was conducted et al.-Azhar University Hospitals, Cairo, Egypt, between 10th October 2020 and 20th December 2020. The study included 100 women aged 20-43 years old undergoing ICSI cycles, with a history of RIF. Patients were divided randomly into two groups group (1) included 50 patients injected with 500 IU of intrauterine HCG on embryo transfer day, and group (2) Included 50 patients injected with G-CSF on the embryo transfer day.RESULTS:
In 100 RIF women, we found a significant improvement in pregnancy outcomes favoring G-CSF over HCG including implantation rate, chemical pregnancy, and clinical pregnancy (P < 0.0001, P = 0.0003, and P = 0.0006, respectively).CONCLUSION:
For the first time, we demonstrated a significant improvement in pregnancy outcomes favoring G-CSF over HCG in terms of implantation rate, chemical pregnancy, and clinical pregnancy. TRIAL REGISTRATION The study was registered on Pan African Clinical Trials Registry with the following number PACTR202010482774275 and was approved on 2nd October 2020.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
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Fator Estimulador de Colônias de Granulócitos
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Injeções de Esperma Intracitoplásmicas
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Gonadotropina Coriônica
Tipo de estudo:
Clinical_trials
Aspecto:
Patient_preference
Limite:
Adult
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
BMC Pregnancy Childbirth
Ano de publicação:
2022
Tipo de documento:
Article