Potent De Novo Macrocyclic Peptides That Inhibit O-GlcNAc Transferase through an Allosteric Mechanism.

Alteen, Matthew G; Peacock, Hayden; Meek, Richard W; Busmann, Jil A; Zhu, Sha; Davies, Gideon J; Suga, Hiroaki; Vocadlo, David J

Alteen, Matthew G; Peacock, Hayden; Meek, Richard W; Busmann, Jil A; Zhu, Sha; Davies, Gideon J; Suga, Hiroaki; Vocadlo, David J.

Afiliação

Alteen MG; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Peacock H; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo, 113-0033, Japan.
Meek RW; York Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5DD, UK.
Busmann JA; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Zhu S; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Davies GJ; York Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5DD, UK.
Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo, 113-0033, Japan.
Vocadlo DJ; Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Angew Chem Int Ed Engl ; 62(5): e202215671, 2023 01 26.

Article em En | MEDLINE | ID: mdl-36460613

Assuntos

N-Acetilglucosaminiltransferases; Peptídeos; Peptídeos/genética; N-Acetilglucosaminiltransferases/genética; N-Acetilglucosaminiltransferases/metabolismo; Mutagênese

Palavras-chave

Allosteric Inhibitor; Glycosyltransferase; O-GlcNAc; Peptide Macrocycle; mRNA Display

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / N-Acetilglucosaminiltransferases Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google